Xanthelasma is a condition that affects the eyelids of around 1-2 percent of the adult population. It is characterized by yellowish plaques on the upper or lower eyelids, most commonly in adults aged 30-60. Although generally harmless, these lesions can be unsightly and cause embarrassment or self-consciousness in those affected. 

Here, we aim to inform you about xanthelasma and provide advice on how to manage and treat it. We will explore topics such as causes and risk factors associated with this condition, diagnosis techniques, available treatments, and lifestyle tips for managing flare-ups. Our goal is to help you gain a better understanding of xanthelasma and manage it effectively.

History and Definition

Xanthelasma is a skin condition characterized by yellow, raised patches or plaques that form on the eyelids. It is a benign condition and is not typically associated with any symptoms other than its cosmetic appearance.

The first documented description of xanthelasma is credited to Erasmus Wilson, a British dermatologist, who described the condition and its distinctive yellow appearance in the late 19th century. The name xanthelasma is derived from the Greek words “xanthos,” meaning yellow, and “elasma,” meaning plate or plaque.


The following are common symptoms of xanthelasma:

  • Yellowish, raised plaques: Xanthelasma appears as yellowish, raised plaques on the skin that are usually less than 1 cm in size. They are most commonly found on the upper or lower eyelids.


  • Soft and flat: Xanthelasma plaques are usually soft and flat to the touch, and they may be slightly tender.


  • Multiple plaques: Xanthelasma plaques may occur in clusters or individually.


  • Asymptomatic: Xanthelasma is usually asymptomatic, meaning that it does not cause any pain or discomfort.

Family history: Xanthelasma may run in families and can be associated with elevated lipid levels, such as high cholesterol or triglycerides.

It is important to note that xanthelasma can be mistaken for other skin conditions, such as chalazion (a small, painless lump in the eyelid) or basal cell carcinoma (a type of skin cancer). If you have any concerns about a skin growth or lesion, it is important to see a dermatologist or a plastic surgeon for an accurate diagnosis.


The exact cause of xanthelasma is not well understood, but several factors have been associated with its development, including:

  • High cholesterol levels: Xanthelasma is often a sign of high cholesterol levels, especially high levels of low-density lipoprotein (LDL) cholesterol, which is known as “bad” cholesterol.


  • Genetics: There may be a genetic component to the development of xanthelasma, as the condition tends to run in families.


  • Age: Xanthelasma is more common in older adults.


  • Gender: Women are more likely to develop xanthelasma than men.


  • Ethnicity: Xanthelasma is more common in people of Asian or Mediterranean descent.

It is important to keep your cholesterol levels in check and to see a doctor if you have any concerns about your health, especially if you have a family history of heart disease or high cholesterol. Xanthelasma can be removed surgically, but it is also important to address the underlying cause, such as high cholesterol levels, to reduce the risk of future problems.


The diagnosis of xanthelasma typically begins with a visual examination of the affected area by a doctor or dermatologist. In most cases, the yellowish deposit of fat that characterizes xanthelasma is easily visible and can be easily diagnosed based on its appearance.

To confirm the diagnosis, the doctor may perform a biopsy, which involves removing a small sample of the affected tissue for laboratory analysis. The biopsy can help to determine the exact type of growth and to rule out other conditions that may have similar symptoms.

In addition to a visual examination and biopsy, the doctor may also order blood tests to check your cholesterol levels and other factors that may contribute to the development of xanthelasma. These tests can help to determine the underlying cause of the condition and to identify any other health problems that may need to be addressed.


Treatment options for xanthelasma may vary based on the individual’s specific case and can include both non-surgical and surgical methods.



  • Topical ointments: Some topical ointments may help to reduce the appearance of xanthelasma, but their effectiveness is limited.


  • Chemical peels: Chemical peels can help to remove the affected tissue, but they may cause some discomfort and have limited effectiveness.


  • Cryotherapy: This procedure involves freezing the affected tissue using liquid nitrogen.


  • Electrodesiccation and curettage (ED&C): In this procedure, an electric current is used to destroy the affected tissue, which is then scraped away with a curette.


  • Surgical excision: This involves surgically removing the affected tissue with a scalpel or scissors.


  • Laser therapy: This involves using a laser to destroy the affected tissue.

Regardless of the treatment option chosen, local anesthesia is typically used to numb the affected area and minimize discomfort during the procedure.

After the treatment, the affected area may be sore and swollen for a few days. The doctor may prescribe pain medication to help manage any discomfort. The area may also be covered with a bandage to protect it from injury.

It is important to keep the affected area clean and dry and to follow any aftercare instructions provided by the doctor to minimize the risk of infection and promote healing. In some cases, there may be some scarring after the procedure, but this is typically minimal and may be hidden by the surrounding skin.

Risk Factors

The following are the risk factors associated with xanthelasma:

  • High levels of cholesterol and triglycerides: Xanthelasma is often a sign of elevated lipid levels in the blood, which can increase the risk of cardiovascular disease.


  • Family history: Xanthelasma can run in families and may be a genetic predisposition.


  • Age: Xanthelasma is more common in older adults, and the risk of developing the condition increases with age.


  • Gender: Women are more likely to develop xanthelasma than men.


  • Ethnicity: Xanthelasma is more common in people of Asian, Mediterranean, and Middle Eastern descent.


  • Hyperlipidemia: This refers to elevated levels of fats in the blood, which can increase the risk of developing xanthelasma.


  • Obesity: People who are overweight or obese are at a higher risk of developing xanthelasma due to the increased levels of lipids in their blood.


  • Poor diet: A diet high in saturated and trans fats can increase the risk of xanthelasma by elevating lipid levels in the blood.

Having one or more of these risk factors does not guarantee that a person will develop xanthelasma, and conversely, some people with xanthelasma may not have any of these risk factors.


Xanthelasma are yellow, raised growths that typically appear on the eyelids and can sometimes cause complications. Some of the most common complications of xanthelasma include:

  • Cosmetics concerns: Xanthelasma can cause cosmetic concerns, especially if they are located in visible areas of the body, such as the eyelids. They can be unsightly and impact a person’s self-esteem and confidence.


  • Interference with vision: Xanthelasma can interfere with vision if they grow large enough to obstruct a person’s field of vision.


  • Recurrence: Xanthelasma can recur after they have been removed, especially if the underlying cause has not been addressed.


  • Risk of underlying disease: Xanthelasma can be a sign of underlying health conditions, such as high cholesterol levels or liver disease.


  • Pain: Xanthelasma can be painful, especially if they are located in an area that is frequently used or if they are large and put pressure on nearby structures.

It’s essential to note that the severity and likelihood of these complications can vary greatly depending on the location, size, and underlying cause of the xanthelasma, as well as the patient’s overall health and the effectiveness of their treatment. If you have xanthelasma, it’s important to seek prompt medical attention to minimize the risk of complications and ensure proper treatment. An underlying health condition, if present, may also need to be addressed.

When to See a Doctor

It is recommended to see a doctor if you notice yellow or pale fatty deposits on or around your eyelids, as these may be signs of xanthelasma. Xanthelasma can sometimes indicate an underlying health condition, such as high cholesterol levels or liver disease, so it is important to seek medical evaluation.

Additionally, if the deposits are causing discomfort, are growing or changing in appearance, or are affecting your vision, it is also important to see a doctor. An eye specialist or a plastic surgeon may be able to diagnose xanthelasma and recommend appropriate treatment options.

Step-by-Step Guide to Xanthelasma Treatment

Here is a step-by-step guide to the treatment of xanthelasma:


During your first appointment, your doctor will perform a thorough evaluation of your skin and medical history. They will also examine the xanthelasma to determine the size, depth, and location of the lesions.

Treatment Options

Based on the examination, your doctor will discuss the various treatment options available for xanthelasma removal. These may include topical creams, laser therapy, surgical excision, cryotherapy, or a combination of these treatments.

Your doctor will help you choose the best treatment option based on factors such as the size and location of the xanthelasma, your age, skin type, medical history, and personal preferences.


If you have decided to go ahead with a procedure, your doctor will give you pre-operative instructions, including information on fasting, avoiding certain medications, and avoiding sun exposure.


The procedure for xanthelasma removal will vary based on the treatment option selected. For example, surgical excision involves cutting out the xanthelasma, while laser therapy uses high-energy light to destroy the lesion. Cryotherapy involves freezing the lesion with liquid nitrogen.

Post-Operative Care

After the procedure, your doctor will provide you with post-operative instructions, including information on wound care, avoiding sun exposure, and avoiding certain activities that could disrupt the healing process.

You will typically need to schedule a follow-up appointment with your doctor to assess the results of the treatment and to determine if any further treatment is necessary.

The exact process may vary depending on the individual case and the doctor’s specific recommendations. It’s important to follow your doctor’s instructions and to attend all scheduled appointments to ensure the best possible outcome.


In conclusion, it is important to note that xanthelasma can be a sign of an underlying health condition and therefore it should not be ignored. While the exact cause of xanthelasma is unknown, it appears to be linked to high levels of cholesterol in the blood as well as certain genetic factors. Treatment involves controlling cholesterol levels through diet and lifestyle modifications, as well as using topical creams or laser treatments to reduce the appearance of xanthelasma. 

If you think you may have xanthelasma, seek medical advice from your doctor for proper diagnosis and treatment options. Remember that taking proactive steps now can help prevent further health issues in the future.


If you’re looking for a top-notch plastic surgeon in the Toronto area, look no further – Dr. Colin Hong has decades of experience and incredibly affordable rates for cosmetic, plastic, and reconstructive surgery services. 

To get started with your consultation, please contact us at (416) 222-6986 or email us at info@drcolinhong.com with your full name, email address, and phone number. Additionally, before setting up an appointment for xanthelasma treatment be sure to have a referral from your family doctor handy. 

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